Research and Publications

Introduction

Metametrix Institute is committed to the translation of proven scientific discoveries and novel uses into clinical practice. To this end, we have established collaborations with university researchers, research institutions, and both pharmaceutical and nutraceutical companies in both basic science and clinical research projects in the areas of cardiology, diabetes, neurology, orthopedics, sports and exercise physiology, nutrition, oncology and perinatal studies. These partnerships have resulted in significant research publications and patent-pending technologies.

Research Partners | Peer Reviewed Journals | Science Publications | Analytical Publications

Research Partners

Universities

• Creighton University – Department of Cardiology

• Emory University – Department of Medicine

• Ohio State University – College of Nursing

• Swedish Medical Center – Center for Perinatal Studies

• University of Pennsylvania – Division of Cardiology

• University of Miami – Department of Cardiology

• Harvard Medical School – Deaconess Hospital Diabetes Center

• Cal State Polytech – Depart of Exercise Physiology and Sports Nutrition

• George Washington University – Lipid Research Clinic

• University of Toledo – Department of Neurology

• Northwestern University – Physical Medicine and Rehabilitation

• Penn State Hershey Med Center – Department of Orthopaedics

• University of Pittsburgh – Dept. of Internal Medicine

• University of Pittsburgh – Dept of Orthopaedic Surgery

• University of Pittsburgh – Cooperative International Neuromuscular Research Group (CINRG)

• University of Texas Medical Center – Division of Cardiology

• Wake Forest (with Cooper Institute) – Dept of Health and Exercise Science

• Loyola University – Stritch School of Medicine

Industries

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Peer Reviewed Journals

Research

Analytical

• Biomedical Chromatography
• Electrophoresis
• Journal of Chromatography and Analytical Technology
• Rapid Communications in Mass Spectrometry

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Science Publications

Fatty Acids

• Effect of omega-3 fatty acid supplementation on the arachidonic acid:eicosapentaenoic acid ratio
  Burns T, Maciejewski SR, Hamilton WR, Zheng M, Mooss AN, Hilleman DE.
  Creighton University School of Pharmacy and Health Professions, Omaha, Nebraska.
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• Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects
  Harper CR, Edwards MC, Jacobson TA.
  Department of Medicine, Emory University, Atlanta, GA 30303, USA. charper@emory.edu
  Read more
• Omega-3 fatty acids effect on wound healing
  McDaniel JC, Belury M, Ahijevych K, Blakely W.
  The Ohio State University, College of Nursing, Columbus, Ohio 43210-1289, USA.
  Read more
• Erythrocyte omega-3 and omega-6 polyunsaturated fatty acids and preeclampsia risk in Peruvian women
  Qiu C, Sanchez SE, Larrabure G, David R, Bralley JA, Williams MA.
  Center for Perinatal Studies, Swedish Medical Center, Seattle, WA.
  Read more
  
  

Lipid Peroxides

• A prospective study of early-pregnancy plasma malondialdehyde concentration and risk of preeclampsia
  Rudra CB, Qiu C, David RM, Bralley JA, Walsh SW, Williams MA
  Center for Perinatal Studies, Swedish Medical Center, Seattle, WA
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ADMA

• Endogenous Nitric Oxide Synthase Inhibitors, Arterial Hemodynamics, and Subclinical Vascular Disease. The PREVENCION Study
  Chirinos JA, David R, Bralley JA, Zea-Díaz H, Muñoz-Atahualpa E, Corrales-Medina F, Cuba-Bustinza C, Chirinos-Pacheco J, Medina-Lezama J
  University of Pennsylvania, Philadelphia; Metametrix Clinical Laboratory, Duluth, Ga; and Santa Maria Catholic University School of Medicine. AQP, Peru
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• Abstract 4054: Determinants of Circulating Asymmetric Dimethylarginine, Monomethylarginine and L-Arginine: A Population-Based Study
  Julio A Chirinos¹; Josefina Medina Lezama²; Robert David³; J. Alexander Bralley³; Oscar L Morey Vargas⁴; Humberto Zea Diaz⁴; Juan F Bolaños⁴; Zoila Valdivia Ascuña⁴; Sheyla Paredes Diaz⁴; Fernando F Corrales Medina⁴; Carolina Cuba⁴; Edgar Muñoz Atahualpa⁴; Julio Chirinos Pacheco⁴
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Organic Acids

• Clinical applications of urinary organic acids. Part I: Detoxification markers
  Lord RS, Bralley JA Metametrix Clinical Laboratory, Duluth, Ga
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IgG Foods

• Case study: The effectiveness of a dietary supplement regimen in reducing IgG-mediated food sensitivity in ADHD
  Ritz BW, Lord RS
  Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania; Metametrix Clinical Laboratory, Duluth, Ga
  Read more
  
  

Estronex

• Estrogen metabolism and the diet-cancer connection: rationale for assessing the ratio of urinary hydroxylated estrogen metabolites
  Lord RS, Bongiovanni B, Bralley JA
  Metametrix Clinical Laboratory, Duluth, Ga
  Read more

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Analytical Publications

Organic Acids

• Analysis of urinary aromatic acids by liquid chromatography tandem mass spectrometry
  Crow B, Bishop M, Paliakov E, Norton D, George J, Bralley JA
  Metametrix Clinical Laboratory, Duluth, GA
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• A simple and cost effective method for the quantification of 8-hydroxy-2'-deoxyguanosine from urine using liquid chromatography tandem mass spectrometry
  Crow B, Bishop M, Kovalcik K, Norton D, George J, Bralley JA
  Metametrix Clinical Laboratory, Duluth, GA
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• High performance liquid chromatography-tandem mass spectrometry (HPLC/MS/MS) assay for chiral separation of lactic acid enantiomers in urine using a teicoplanin based stationary phase
  Norton D, Crow B, Bishop M, Kovalcik K, George J, Bralley JA
  Metametrix Clinical Laboratory, Duluth, GA
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Amino Acids

• Direct analysis of un-derivatized asymmetric dimethylarginine (ADMA) and L-arginine from plasma using mixed-mode ion-exchange liquid chromatography-tandem mass spectrometry
  Bishop MJ, Crow B, Norton D, Paliakov E, George J, Bralley JA
  Metametrix Clinical Laboratory, Duluth, GA
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• A simple and selective method for the measurement of leucine and isoleucine from plasma using electrospray ionization tandem mass spectrometry
  Bishop MJ, Crow B, Norton D, Kovalcik K, George J, Bralley JA
  Metametrix Clinical Laboratory, Duluth, GA
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Fat-Soluble Vitamins

• Rapid quantitative determination of fat-soluble vitamins and coenzyme Q-10 in human serum by reversed phase ultra-high pressure liquid chromatography with UV detection.
  Paliakov EM, Crow BS, Bishop MJ, Norton D, George J, Bralley JA
  Metametrix Clinical Laboratory, Duluth, GA
  Read more

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