Humans can display a range of coenzyme Q10 (CoQ10) levels in serum, yet high circulating CoQ10 does not indicate it is sufficient for production of ATP in the mitochondrial electron transport chain. Using statin drugs can interfere with CoQ10 production, compromising cellular energy production. High performance athletes are candidates for testing CoQ10, as well as patients that appear to have mitochondrial dysfunction, neurological or skeletal muscle disorders. Cases of genetic inability to produce adequate CoQ10 have been identified and treated successfully with CoQ10. This article illustrates that measuring both direct and indirect biomarkers of CoQ10 sufficiency in order to appropriately diagnose and treat patients, and to monitor CoQ10 administration, can markedly improve patient outcomes and prevent mitochondrialrelated disease...

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Nelson-Dooley C, Lord RS, Bralley JA, "Why Test for Coenzyme Q10?" Metametrix White Paper (PDF) 2006.